Response to “When can AQP4 assist transporter-mediated K+ uptake?”
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Response to “When can AQP4 assist transporter-mediated K+ uptake?”
We thank Hertz et al. for their comments and suggestions in this issue regarding alternative mechanisms that might be involved in the apparent coupling of K + and water in brain extracellular space (ECS). The mechanism examined in our model (Jin et al., 2013) is based on simple physical chemistry: uptake of ECS K + after release from neurons produces an osmotic driving force for water uptake by...
متن کاملWhen can AQP4 assist transporter-mediated K+ uptake?
We agree with Jin et al. (2013) that astrocytes accumulate extracellular K +. They discuss how differences in (a) resting extracellular space (ECS) volume, (b) diffusion limited water/K + transport, and (c) ECS contraction during K + reuptake may differently affect astrocytic K + uptake in wild-type animals and in mice with aqua-porin-4 (Aqp4) knockout. The first of these factors is well studie...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2013
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.201311010